Not simply misshapen red cells : multimolecular and cellular events in sickle vaso - occlusion

نویسنده

  • Leon H. Charney
چکیده

1. Sotoodehnia N, et al. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010;42(12):1068–1076. 2. Holm H, et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet. 2010;42(2):117–122. 3. Pfeufer A, et al. Genome-wide association study of PR interval. Nat Genet. 2010;42(2):153–159. 4. Chambers JC, et al. Genetic variation in SCN10A influences cardiac conduction. Nat Genet. 2010; 42(2):149–152. 5. Akopian AN, Sivilotti L, Wood JN. A tetrodotoxinresistant voltage-gated sodium channel expressed by sensory neurons. Nature. 1996;379(6562):257–262. 6. Chen Q, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998;392(6673):293–296. 7. Probst V, et al. Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenegre disease. J Am Coll Cardiol. 2003;41(4):643–652. 8. Papadatos GA, et al. Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A. 2002;99(9):6210–6215. 9. Bezzina CR, et al. Common variants at SCN5ASCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet. 2013;45(9):1044–1049. 10. Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM. Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ Res. 2012;111(3):322–332. 11. Verkerk AO, et al. Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology. Circ Res. 2012;111(3):333–343. 12. van den Boogaard M, et al. A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest. 2014;124(4):1844–1852. 13. Arnolds DE, et al. TBX5 drives Scn5a expression to regulate cardiac conduction system function. J Clin Invest. 2012;122(7):2509–2518. 14. van den Boogaard M, et al. Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. J Clin Invest. 2012; 122(7):2519–2530. 15. Dun W, Boyden PA. Does SCN10A gene product play a role in canine Purkinje cell electrophysiology? Poster presented at: Heart Rhythm 2012: 33rd Annual Scientific Sessions; May 9–12, 2012; Boston, Massachusetts, USA. 16. Facer P, et al. Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart. Int Heart J. 2011;52(3):146–152. 17. Yang T, Atack TC, Abraham RL, Darbar D, Roden DM. Striking electrophysiologic differences between cardiac sodium channel isoforms SCN10A and SCN5A [abstract]. Circulation. 2011;124:A16237. 18. Hu D, et al. Genetic Variants in SCN10A Associated with Brugada Syndrome, Right Bundle Branch Block and Atrioventricular Block. Poster presented at: Heart Rhythm 2012: 33rd Annual Scientific Sessions; May 9–12, 2012; Boston, Massachusetts, USA. 19. Clatot J, et al. Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits. Cardiovasc Res. 2012;96(1):53–63. 20. Qi B, et al. Nav1.8 channels in ganglionated plexi modulate atrial fibrillation inducibility [published online ahead of print February 2, 2014]. Cardiovasc Res. doi:10.1093/cvr/cvu005. 21. Blasius AL, et al. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A. 2011;108(48):19413–19418.

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تاریخ انتشار 2014